Methods for development of hybrid tissue engineered valve with polyurethane …

This invention describes a heart valve leaflet built around a core made from a specific type of plastic, like carbothane. This plastic core is then fully encased by two layers of a patient's cells: an inner layer of smooth muscle or fibroblast cells, and an outer layer of endothelial cells. The goal is to create a functional, living component for a replacement heart valve.

Why it matters: Filed before significant advancements in 3D bioprinting and bioreactor technology made the precise layering and maturation of such complex cell-material constructs more feasible and reproducible.

Status: Not in forceListed as no longer active. The specific reason is not in the record we hold.
How hard to build: SpecializedCell culture, biomaterial fabrication, sterile assembly

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