Genetically modified bacteria and methods for genetic modification of bacteria

This invention describes a pharmaceutical composition containing a specific type of genetically modified bacteria, *Propionibacterium acnes* (P. acnes). This modified P. acnes is engineered to produce beneficial mammalian growth factors or cytokines, intended for use as a medicine to treat skin conditions in mammals.

Why it matters: Since 2015, genetic engineering tools like CRISPR have significantly advanced the precision and ease of modifying bacteria. Concurrently, the understanding and therapeutic potential of the skin microbiome for dermatological conditions have greatly expanded, making targeted bacterial interventions more viable.

Status: Not in forceListed as no longer active. The specific reason is not in the record we hold.
How hard to build: SpecializedGenetic engineering, microbiology, pharmaceutical formulation.

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