This invention describes a way to deliver anticancer drugs directly to cancer cells using tiny fat-based spheres called liposomes. These liposomes are designed to carry the drug and also have special tags, like peptides or antibodies, on their surface that help them find and attach to specific cancer cells. The liposomes are built from common fats, a special fat that helps them avoid the body's defenses, and the targeting tag attached via a flexible chain.
Why it matters: Since 2014, significant advancements in targeted drug delivery, particularly in the rational design and synthesis of highly specific targeting ligands and improved methods for their conjugation to stable liposomal systems, could enhance the efficacy and reduce off-target effects of such drug delivery systems.
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