This invention describes a system that uses a laser to shine light on individual cells flowing through a tiny channel. The laser makes the DNA inside the cell vibrate, and the system then detects these unique vibrations. By analyzing these vibrations, it can figure out how the DNA is folded or packed, specifically designed for unstained sperm cells.
Why it matters: Advancements in label-free single-cell analysis and spectroscopic sensitivity over the past decade could make this approach more practical. The ability to analyze unstained cells, especially sperm, has become increasingly valuable in reproductive health and research.
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